What is the microbiome?
Our human digestive tract is home to one of the most dense and diverse microbial ecosystems in the known universe. Trillions of microbes call us home. These microbial communities, the habitat they live in, and their repertoire of activity are known as the ‘gut microbiome’. Research has shown that the gut microbiome performs many crucial bodily functions, such as digesting food, protecting us against harmful bacteria, and supporting our immune system.
In health, the microbial communities that inhabit the microbiome work in harmony and are said to live in symbiosis. However, imbalances in both structure and function can occur. These imbalances, sometimes called ‘dysbiosis’ have been shown across numerous studies to be associated with a wide range of intestinal and extra-intestinal diseases.
What happens when the microbiome is unbalanced?
Studies show that imbalances in the microbiome are associated with intestinal diseases, ranging from acute intestinal infections caused by the bacterium C.difficile, to complicated chronic conditions like inflammatory bowel disease and colorectal cancer. The impact of imbalances within the gut microbiome may even reach other parts of the body, with studies linking imbalances in the microbiome to diseases of the brain and nervous system such as Parkinson’s disease and Multiple Sclerosis.
Restoring balance and treating disease
Many of the diseases and infections associated with imbalances in the gut microbiome are challenging to treat and can be fatal. Our increasing understanding of the deleterious biological effects of aberrant gut microbiome composition and function is allowing the scientific and medical community to explore the gut as an exciting potential therapeutic avenue in these patients.
EnteroBiotix is pioneering novel microbiome modulating drugs that aim to restore health and prevent disease. The Company’s three core product pipelines build on the science of a medical treatment called Faecal Microbiota Transplantation (FMT). With deep operational experience, capabilities, proprietary technology and know-how, EnteroBiotix is well positioned to develop and advance this new generation of therapeutics,